Anthracyclines
نویسندگان
چکیده
منابع مشابه
Anthracyclines and heart failure.
Since their discovery more than 50 years ago, anthracyclines have become the mainstay for the treatment of many cancers. However, anthracyclines are associated with a risk of heart failure, with the risk proportionate to the cumulative exposure; cardiac injury appears to occur with every dose, and cardiac-biopsy specimens obtained within hours after a single dose of an anthracycline (e.g. doxor...
متن کاملAnthracyclines and the heart.
The anthracyclines are effective and widely used antineoplastic agents. They are used to treat many types of malignancy including acute lymphoblastic leukaemia.' Their introduction has considerably improved survival, especially in childhood cancers. Signs of cardiac toxicity may develop during, soon after or many years after a course of treatment. Early toxicity is dependent principally on the ...
متن کاملAnthracyclines: cardiotoxicity and its prevention.
The anthracycline antibiotics have now been in use in curative chemotherapy protocols for over two decades. They are highly active against a wide range of haemopoietic and solid tumours in children and adults. Unfortunately, their antineoplastic use is limited by significant and irreversible cardiotoxicity, the full extent of which continues to emerge. As more children become long term survivor...
متن کاملRadiotherapy and anthracyclines – cardiovascular toxicity
The subject of this paper is to analyze the impact of radiotherapy and anthracyclines on the cardiovascular system, based on a survey of contemporary literature. Currently, high efficiency of anticancer therapies has increased the rate of survival in patients treated for cancer. It should be emphasized, however, that these treatments damage not only the affected but also the healthy tissue. Con...
متن کاملRedox Cycling of Anthracyclines by Cardiac Mitochondria
In the accompanying paper (Davies, K. J. A., and Doroshow, J. A. (1986) J. Biol. Chern. 261, 30603067), we have demonstrated that anthracycline antibiotics are reduced to the semiquinone form at Complex I of the mitochondrial electron transport chain. In the experiments presented in this study we examined the effects of doxorubicin (Adriamycin), daunorubicin, and related quinonoid anticancer ag...
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ژورنال
عنوان ژورنال: WikiJournal of Medicine
سال: 2018
ISSN: 2002-4436
DOI: 10.15347/wjm/2018.001